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Center for Biopharmaceutical Operations
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| Overview |
The University of California at Berkeley’s Center for Biopharmaceutical Operations (CBO) brings together academic researchers having diverse industrial experience with biopharmaceutical operations managers and engineers to develop practical methodologies, measures, and tools for the design and operation of cost-effective, reliable production and logistics systems for manufacturing and distributing safe, effective drugs.
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| CBO activities |
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Foster collaboration between academia and industry through joint tool development and student projects.
Facilitated pre-competitive collaboration among different companies
Technical seminars and workshops with industry
Educating and training world-class students in bioproduction and logistics
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| Key focus |
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The Center for Biopharmaceutical Operations' key focus is on the following issues of production for Biopharmaceutical manufacturers: |
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Supply chain optimization, including outsourcing and reliability
Operational production planning and scheduling
Tactical production facility and logistics system design including demand forecasting and simulation
Strategic long-range planning and risk management
Measuring and controlling supply chain and production uncertainty
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Garbage In, Garbage Out: The Case for More Accurate Process Modeling in Manufacturing Economics
Current biotech manufacturing plants are capital intensive, with yearly depreciation costs sometimes as high as raw materials costs. In such an environment where indirect costs dominate direct charges, a single metric becomes important: throughput of sale-able product. In this article, we examine a return-on-investment case study for processing a high titer product in a large-scale biopharmaceutical plant. In this case, modeling the altered unit operation in the context of the existing unit operations was essential to establish accurate throughput metrics and overall valuation. We argue that such process-focused economics models are essential in the biopharmaceutical industry.
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Foundations for Bioproduction
Recent CITRIS and IEOR collaboration on research into the Foundations for Bioproduction. This research aims to bring further understanding of the key issues in bioproduction which are unique to that industry.
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The Birth of Bioproduction at UC Berkeley
When Berkeley professor Lee Schruben attended a conference celebrating the opening of Berkeley's new Department of Bioengineering, he was duly impressed. One after another, researchers highlighted new research on methods to treat myriad diseases that could someday save "millions of lives." But as much as Schruben, the chair of the Department of Industrial Engineering and Operations Research (IEOR), was impressed by the presentations, he was also concerned. A new drug to combat multiple sclerosis, for example, is only a lifesaver if it gets to the patients who need it at a cost they can afford. This is a problem, Schruben realized, that falls squarely in the IEOR domain.
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Department of Industrial Engineering and Operations Research
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With its distinguished faculty, competitive student body and wonderful support staff, the IEOR department is one of the finest schools of Industrial Engineering/Operations Research in the world. The department is ranked 2nd in the U.S. by the National Research Council.
IEOR faculty are world-renowned experts in many application areas, from semiconductor manufacturing to the design and deregulation of energy markets to supply chain management to robotics to discrete event simulation, and have made important advancements in the theory of operations research, in areas such as algorithm design, integer programming, non-linear programming, and stochastic modeling. Faculty include fellows of professional societies such as INFORMS, IEEE, ACM.
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CITRIS
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The Center for Information Technology Research in the Interest of Society –CITRIS—creates information technology solutions for many of our most pressing social, environmental and healthcare problems.
The first public-private partnership created to use IT in this way, CITRIS partners more than 300 faculty and thousands of students from myriad departments at four UC campuses (Berkeley, Davis, Merced and Santa Cruz) with industrial researchers from over 60 corporations. |
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